M Asaizumi, RL Karlinsey, AC Mackey, T Kato, T Kuga. In vitro assessments of white-spot lesions treated with NaF plus tricalcium phosphate (TCP) toothpastes using microtomography (micro-CT). Journal of Dentistry & Oral Hygiene 5, 68 (2013).
Abstract
X-ray microtomography (micro-CT) was used to assess the densities of white-spot lesions (WSL) treated with either a fluoride-free paste, or 0.21 or 1.1% NaF toothpastes containing functionalized tricalcium phosphate (TCP). Bovine enamel specimens were ground, polished and demineralized to form WSL. Specimens (N=10) were treated with one of the following NaF silica-based toothpastes in a 10-day pH cycling model: (1) Tom’s of Maine (0% NaF), (2) Clinpro™ Tooth Crème (0.21% NaF plus TCP), and (3) Clinpro™ 5000 (1.1% NaF plus TCP). Each day consisted of four 2 min treatments, one 4 h acid challenge (pH=5.0), and immersion in artificial saliva (pH=7.0) between these events. After cycling, specimens were analyzed using micro-CT. Statistical analysis (Student’s t-test, Welch t-test or Tukey HSD test) was performed at the 95% confidence level. Compared to sound enamel, significantly (p<0.05) lower densities in WSL were only found at 24 μm from Clinpro™ Tooth Crème, and at 36 μm from Clinpro™ 5000. In contrast, the densities measured at 12, 24, 36, and 48 μm from the fluoride-free toothpaste were lower (p<0.05) than sound enamel. Micro-CT analyses revealed NaF toothpastes containing TCP led to increased WSL densities relative to the fluoride-free toothpaste.
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Dr. Robert L. Karlinsey earned a BS in Physics and PhD in Chemical Physics, holds several patents, and has published in multiple fields including dentistry, chemistry, and materials science. His lifelong struggles with his own dental decay ultimately inspired him to investigate the remineralization of teeth.