M Asaizumi, RL Karlinsey, AC Mackey, T Kato, T Kuga. In vitro assessments of white-spot lesions treated with NaF plus tricalcium phosphate (TCP) toothpastes using microtomography (micro-CT). Journal of Dentistry & Oral Hygiene 5, 68 (2013).
X-ray microtomography (micro-CT) was used to assess the densities of white-spot lesions (WSL) treated with either a fluoride-free paste, or 0.21 or 1.1% NaF toothpastes containing functionalized tricalcium phosphate (TCP). Bovine enamel specimens were ground, polished and demineralized to form WSL. Specimens (N=10) were treated with one of the following NaF silica-based toothpastes in a 10-day pH cycling model: (1) Tom’s of Maine (0% NaF), (2) Clinpro™ Tooth Crème (0.21% NaF plus TCP), and (3) Clinpro™ 5000 (1.1% NaF plus TCP). Each day consisted of four 2 min treatments, one 4 h acid challenge (pH=5.0), and immersion in artificial saliva (pH=7.0) between these events. After cycling, specimens were analyzed using micro-CT. Statistical analysis (Student’s t-test, Welch t-test or Tukey HSD test) was performed at the 95% confidence level. Compared to sound enamel, significantly (p<0.05) lower densities in WSL were only found at 24 μm from Clinpro™ Tooth Crème, and at 36 μm from Clinpro™ 5000. In contrast, the densities measured at 12, 24, 36, and 48 μm from the fluoride-free toothpaste were lower (p<0.05) than sound enamel. Micro-CT analyses revealed NaF toothpastes containing TCP led to increased WSL densities relative to the fluoride-free toothpaste.
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