RL Karlinsey, AC Mackey, ER Walker, KE Frederick, CX Fowler. In vitro evaluation of eroded enamel treated with fluoride and a prospective tricalcium phosphate agent. Journal of Dentistry & Oral Hygiene 1, 52 (2009).
The anti-erosion effects of 225 ppm fluoride plus an innovative form of tricalcium phosphate (TCP-Si-Ur) relative to 225 ppm fluoride were investigated using a pH cycling model comprising treatment, saliva and acid challenge periods. Polished bovine enamel specimens were initially softened in 1% citric acid (pH = 3.8) and stratified (N = 10) into the following groups according to their Vickers microhardness: water, 225 ppm fluoride and 225 ppm fluoride containing 20, 40, or 80 ppm TCP-Si-Ur. The cycling regimen consisted of three two-minute treatment periods and five two-minute acid challenges (1% citric acid, pH = 3.8) per day for a total of 20 days. Surface microhardness measurements were made at 10 and 20 days. After 10 days, statistical differences (t-tests, p < 0.05) only existed between water and each of the four fluoride-containing groups. After 20 days, significant differences were observed among the fluoride-containing groups, with fluoride plus 20 ppm TCP-Si-Ur providing significant surface strengthening relative to fluoride alone. Cross-sectional microhardness measurements revealed distinctly different strength profiles and infrared spectroscopy was employed to probe possible changes in enamel microstructure. Collectively, our results indicate a synergistic effect can be produced when TCP-Si-Ur is combined with fluoride and administered to eroded enamel.
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