RL Karlinsey, AC Mackey, ER Walker, KE Frederick. Surfactant-modified β-TCP: structure, properties, and in vitro remineralization of subsurface enamel lesions. Journal of Materials Science: Materials in Medicine 21, 2009 (2010).
A hybrid material comprised of beta-tricalcium phosphate (β-TCP) and sodium lauryl sulfate (SLS) was prepared using a mechanochemical process, examined using particle size analysis, IR spectroscopy, ³¹P, ²³Na, and ¹³C solid-state NMR spectroscopy, and calcium dissolution experiments, and probed for in vitro remineralization of subsurface enamel lesions. Our results suggest that while the ³¹P environments of β-TCP remain unchanged during solid-state processing, there is noticeable shifting among the SLS ²³Na and ¹³C environments. Therefore, given the structure of β-TCP, along with our IR examinations and calcium dissolution isotherms, SLS appears to interface strongly with the cation deficient C₃ symmetry site of the β-TCP hexagonal crystal lattice with probable emphasis placed on the underbonded CaO₃ polyhedra. To demonstrate the utility of the surface-active TCP material in dental applications, we combined the TCP–SLS with 5,000 ppm F (NaF) and evaluated the remineralization potential of subsurface enamel lesions via an in vitro remineralization/demineralization pH cycling dental model. Using surface and longitudinal microhardness measurements, the TCP–SLS plus 5,000 ppm F system was found to significantly boost remineralization of subsurface enamel lesions, with microhardness values increasing up to 30% greater than fluoride alone.
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